Functional Neural Transplantation

by Stephen B. Dunnett

Summary

In this volume, leading international experts review the present status of all major areas of research in functional neural transplantation. The contributors assess the capacity of neural grafts to repair the structural damage and alleviate the functional consequences of brain damage and neurodegenerative disease. The book begins with detailed coverage of dopamine-rich grafts in parkinsonism, including analyses of the first clinical studies. The authors then review the results of neural grafts in experimental models of cholinergic deficiency, aging, and dementia. Full consideration is given to transplantation strategies used in various neural systems such as the cortex, visual system, hypothalamus, and spinal cord. The final chapter reviews the pharmacological, trophic, and regenerative mechanisms of neural grafts in the brain.